Plasma Therapies


Haemoperfusion Cartridge

Product Description

The HA380 is a Haemoperfusion cartridge that can be used as a stand alone device or in conjunction with other other extra-corporeal therapies.

The HA380 has the ability to remove pro-inflammatory cytokines in cytokine storm and other cellular inflammatory markers.

Clinical Indications Include:

  • Patients unresponsive to vasopressor support after fluid resuscitation
  • Hyper-lactataemia not responding to standard of care
  • COVID-19 rescue therapy (2 + 1 + 1 therapy) See publication 1
  • Patients unresponsive to standard of care who have multiple organ failure
  • Patients exhibiting signs of Damage Associated Molecular Patterns (DAMPS) or Pathogen Associated Molecular Patterns (PAMPS)
  • Intra-operative cardiac surgery where the patient already has significant pre-existing cellular inflammatory activation caused by  Heart Failure or where a VAD device has been implanted etc.
  • Patients requiring long pump procedures such as Heart / Lung transplant and other procedures.
  • Respiratory failure
  • Conjunctive therapy with ECMO

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Using the Jafron Adsorber in COVID-19 Patients
Organ Crosstalk in Critical Illness
HA380                      Product Description
HA380 Haemoperfusion Cartridge 1 unit

Technical Details:

Product parameter   HA380
  Loading capacity (ml)   380±3
  Volume (ml)   150±5
  Absorbent material   Styrene divinybenzene copolymers
  Housing material   Polycarbonate
  Sterilization method   Irradiation sterilization
  Packaging size   290mm(L)×105mm(W)×105mm(H) 0.90kg
  • Webinar Timestamps - Using the Jafron Adsorber in COVID-19 Patients

    29:40 – 44:10: Pathogenesis of AKI and cytokine storm

    45:50 – 52:48: Haemoperfusion in the absence of AKI or in RRT

    57:40 – 101:17: Usage of the Jafron Adsorber in severe COVID-19 patients (Thailand)

    105:46 – 119:00: COVD-19 experience in Thailand with Jafron Adsorber

  • Webinar Timestamps - Organ Crosstalk in Critical Illness

    34:12 – 43:31  Rational of blood purification on Covid-19 patients

    52:49 – 58:05    Evidence of Hemoperfusion for ARDS – Clinical study

    58:36 – 1:04.43   When to start Hemoperfusion?

    1:10.50 – 1:12.55  Sometimes there is a rebound of biomarkers after Hemoperfusion. Why?

    1:16.38 – 1:18.50  When do we stop Hemoperfusion?

    1:18.52 – 1:21.53   Is viral load measurement important when considering performing Hemoperfusion?

    1:24.55 – 1:28.30   Summary ( Early therapy)

  • COVID-19: The use of Jafron Adsorber in severely ill patients

  • Cytokine adsorption devices for treating respiratory failure in people with COVID-19

  • Cytokine adsorbers for the treatment of cytokine storm in people with severe coronavirus infection (Health Technology Wales Topic Exploration Report)

  • Extracorporeal Techniques

  • COVID-19: consider cytokine storm syndromes and immunosuppression

  • Effect on Extrapulmonary Sepsis-Induced Acute Lung Injury by Hemoperfusion With Neutral Microporous Resin Column

  • Coronavirus Epidemic and Extracorporeal Therapies in Intensive Care

  • Hemodialysis – Review Article

  • Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan

  • Clinician Questions

    Clinicians are often asking the question, “When should I start Cytokine adsorption therapy for it to be most effective?”  We have put together a list of indicators when to start treating Covid 19 patients using the Jafron Cytokine Haemoperfusion adsorption device based on an  overall consensus of opinion from clinicians managing patients with Covid-19. These indications are not exhaustive and definitive but a guide.

    • Ferritin >500ng/mL;
    • C-Reactive Protein (CRP) >70mg/L;
    • D-Dimer >1000ng/mL;
    • Lactate Dehydrogenase (LDH) >300U/L;
    • Lymphocyte Count <0.8 billion/L)
    • ARDS not responding to prone position (PaO2/FiO2 ratio > 100 mmHg)
    • Increasing Vasopressor support after fluid resuscitation
    • Worsening Hyper-lactataemia
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